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KMID : 1040620150210040379
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Clinical and Molecular Hepatology
2015 Volume.21 No. 4 p.379 ~ p.386
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Effect of vitamin E in nonalcoholic fatty liver disease with metabolic syndrome: A propensity score-matched cohort study
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:Kim Gi-Hyun
:Chung Jung-Wha/:Lee Jong-Ho/:Ok Kyeong-Sam/:Jang Eun-Sun/:Kim Jai-hwan/:Shin Cheol-Min/:Park Young-Soo/:Hwang Jin-Hyeok/:Jeong Sook-Hyang/:Kim Na-Young/:Lee Dong-Ho/:Kim Jin-Wook
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Abstract
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Background/Aims: Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome.
Methods: A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85).
Results: The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P<0.01). The changes in metabolic profiles (body weight, lipid and glucose levels) did not differ between control and vitamin E groups during the study period.
Conclusions: Short-term vitamin E treatment significantly reduces ALT levels in NAFLD patients with metabolic syndrome, but metabolic profiles are not affected by vitamin E.
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KEYWORD
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Nonalcoholic fatty liver disease, Vitamin E, Metabolic syndrome, Propensity score
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